Facile Synthesis of Tetrahydroimidazolpyridinones via an MCR Involving 6-Cl-PMNI, Aldehydes, and Meldrum's Acid

Abstract

Tetrahydroimidazolpyridinones 2, which are new, highly bioactive potential insecticides, were prepared in 30–96% yield through a multicomponent reaction (MCR) of 6-Cl-PMNI, aldehydes, and Meldrum's acid using catalytic Et₃N or K₂CO₃ in anhydrous CH₃CN at refluxing temperature.

Keywords:

• 6-Cl-PMNI
• insecticide
• Meldrum's acid
• multicomponent reaction
• tetrahydroimidazolpyridinone

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Corrigenda

ACKNOWLEDGMENTS

This work was financially supported by the Shanghai Committee of Science and Technology (No. 064319022), the New Century Excellent Talents in University, the Ministry of Education, China (No. NCET-07-0283), the Natural Science Foundation of China (No. NSFC 20602011), and the “111” Project (No. B07023).

Notes

^a Yield of isolated and purified products.

^b Showing high insecticidal activities against pea aphids.^{[ 5 ]}