Chemoselective Protection and Deprotection of Aldehydes Using Solid Supported Reagent (Silica Chloride) Under Solvent-Free Conditions

Abstract

Silica chloride, a heterogeneous catalyst, has been found to be an efficient catalyst for the protection of aldehydes as acylals under solvent-free conditions, and deprotection of acylals to aldehydes in methanol as a solvent occurred. The reaction takes a shorter time and ensures good to excellent yield of the products.

Keywords:

• Acylals
• aldehydes
• deprotection in methanol
• heterogeneous catalysis
• silica chloride

Notes

^a Isolated yield.

^a All the acylals were characterized by comparison of the melting points with authentic samples [Refs. 27, 29] and by the IR spectral analysis.

^b Deprotection was followed by GC-MS analysis.

^c Isolated yields.

^d ND, not detected.