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An asymmetric synthesis of (S,S,S)-2-aza-bicyclo-[3.3.0]-octane-3-carboxylic acid benzyl ester 2 as an intermediate of angiotensin converting enzyme (ACE) inhibitor, ramipril 1, is described.
We greatly appreciate Prof. Dieter Enders for his promptness in sharing documents related to SAMP. We are also thankful to the management of Dr. Reddy's Laboratories Ltd. for supporting this work.
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