Abstract
17–Esters of corticosteroids have received considerable attention due to their high topical anti-inflammatory activity. one of the best known is betamethasone 17-valerate which is widely used against a variety of skin diseases2. The relatively simple compound, hydrocortisone 17–butyrate (3a)3 proved to be as active topically as the more sophisticated corticosteroids such as triamcinolone acetonide, while its systemic activity is of the same order as that of hydrocortisone4.