Synthetic Studies Related to Illudinine - A Sesquiterpene Alkaloid

Abstract

Illudinine (1)¹ has special significance because of its biogenetic relations to illudalic acid, a sesqui-terpenoid with protoilludane skeleton. All these compounds possess highly pronounced physiological properties. For entry into the synthesis of the alkaloid (1) incorporating the sesquiterpene skeleton, the successful synthesis of (12) having all the C₁₅-carbon atoms of (1) is described, along with a model study to build up the heterocyclic ring system (13).