Conjugated Addition to 2,2-Dimethyl-3(2h)-furanone: Support for the Baldwin Rules for Ring Closure

Amos B. Smith The Department of Chemistry, The Monell Chemical Senses Center and The Laboratory for Research on the Structure of Matter, Philadelphia, Pennsylvania, 19104; The University of Pennsylvania, Philadelphia, Pennsylvania, 19104

Paula J. Jerris The Department of Chemistry, The Monell Chemical Senses Center and The Laboratory for Research on the Structure of Matter, Philadelphia, Pennsylvania, 19104; The University of Pennsylvania, Philadelphia, Pennsylvania, 19104

Abstract

In connection with our exploratory studies directed at devising a total synthetic approach to jatro-phone¹ and related antitumor agents,² we have recently explored conjugate addition of organocuprates³ to the 3 (2H)-furanone ring system. In this letter we document the results of that study.

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Conjugated Addition to 2,2-Dimethyl-3(2h)-furanone: Support for the Baldwin Rules for Ring Closure

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Conjugated Addition to 2,2-Dimethyl-3(2h)-furanone: Support for the Baldwin Rules for Ring Closure

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