Method for Conversion of α-Ketols to Ketones. Deoxygenation with Iodotrimethylsilane

Abstract

Iodotrimethylsilane has rapidly become a valuable reagent for organic synthesis since its use in the cleavage of alkyl esters and ethers^1,2,3 under essentially neutral conditions was introduced. For example, the conversion of ketals to ketones⁴, alcohols to iodides⁵, alkyl carbamates to amines, and sulfoxides to sulfides⁷ can now be readily promoted by iodotrimethylsilane.