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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 11, 1981 - Issue 7
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Original Articles

Use of Methyl 3- (N, N-Dimethylamino) Propionate as a Synthon for the Construction of α-Methylene γ-Butyrolactones

Lin-Chen Yu Department of Chemistry, State University of New York, Stony Brook, New York, 11794, USA
&
Paul Helquist Department of Chemistry, State University of New York, Stony Brook, New York, 11794, USA
Pages 591-597 | Published online: 05 Dec 2006
 
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Abstract

The lithium enolate of methyl 3-(N, N-dimethylamino) propionate reacts with allylic halides to give alkylation products which may be converted into α-methylene γ-butyrolactones by a reaction sequence which includes iodolactonization among other simple steps.

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