Reactions of 1,2-Epoxy-2-Methyl-3-butene with Lithio Derivatives of Allylic Sulfoxides. Syntheses of 2,6-Dimethylocta-3,7-dien-2,6-diol and of 5,8-Dehydro-4-0xo-nerolidol

Abstract

Our preceding studies have shown that lithio carbanions of protected cyanohydrins can undergo Michael additions to an isoprenic sulfoxide to yield lithio derivatives of allylic sulfoxides¹. These results have led us to investigate the utilization of these lithio sulfoxides for new simple syntheses of aliphatic terpenes by head-to-tail linking of functionalized isoprenoid units. For this purpose, 1,2-epoxy-2-methyl-3-butene 2 was one especially appropriate electro-phile, but at the outset of our work, there had been very few investigations of the reactivity of lithio carbanions of allylic sulfoxides with epoxides²