Conformational Analysis of Four Stereoisomeric Methyl 3-Acetoxy-2-Butyl-1-Cyclohexanecarboxylates and Their Derivatives in Solution

Abstract

The conformational analysis of six-membered ring compounds such as mono- and disubstituted cyclohexane is a well-documented subject, and hence prediction of the most stable conformation of a given compound can be in general achieved with reasonable accuracy either by use of thermodynamic data or by spectroscopic methods.¹⁾ When considering polysubstituted cyclohexane, the configurational and the conformationay possibilities become large. The conformational aspects of 1,2,3-trisubstituted cyclohexanes would be complex depending on the nature of substituents because so many parameters are involved.¹⁾