Reaction of α-Halo-Enones with Heterocyclic Bases. A Mild and Efficient Synthesis of Amino-Steroids

Abstract

A number of steroids containing cyclic amino functions have been prepared and studied for biological activities, and some of them have proved to be clinically useful as a neuromuscular blocking agent, an antitumour agent, and so on.¹ As the conventional methods, the reactions of cyclic amines with halides² or epoxides,³ the reductive amination of ketones,⁴ and the reduction of enamines⁵ have been widely used for introducing these amino functions into steroid nucleus.