Strategy and Construction of the Backbone Bistetrahydrofuran System Towards Synthesis of Rollinicin

Abstract

Rollinicin¹ (I), uvaricin² (II) and cherimoline³ (III), the new antitumour, antibiotic agents, isolated from renewable resources having bistetrahydrofuran ring system in the molecules, have been recently reported. Bates² has postulated that uvaricin has been probably biosynthesised from 1,5,9-trienoic acid derivative. The central portion of I - III, a bistetrahydrofuran ring system, is apparently novel. This prompted us to develop a methodology for the construction of the central bistetrahydro-furan ring system (L) using acetylenic derivatives as the starting materials for the first time. In this communication, we report 4 its result.