Approach to Synthesis of γ-Aminobutyric Acid (GABA) Analogues with Rigid Conformations - Convenient One Pot Synthesis of Functionalized Bisnaphthalenes

Abstract

Silica gel supported cerium (IV) ammonium nitrate has been successfully employed to achieve functionalized C-C-linked bisnaphthalenes. The study demonstrates the utility of silica gel support for controlling over oxidation in cerium (IV) based oxidants and is of significance to prepare GABA analogues with restricted conformation required for studying GABAergic processes in neurochemical investigations.