A New Synthesis of Polysubstituted Cyclopropanes

Ryuji Yoneda Osaka University of Pharmaceutical Sciences, 2-10-65, Kawai, Matsubara, Osaka, 580, Japan

Kazunori Santo Osaka University of Pharmaceutical Sciences, 2-10-65, Kawai, Matsubara, Osaka, 580, Japan

Shinya Harusawa Osaka University of Pharmaceutical Sciences, 2-10-65, Kawai, Matsubara, Osaka, 580, Japan

Takushi Kurihara Osaka University of Pharmaceutical Sciences, 2-10-65, Kawai, Matsubara, Osaka, 580, Japan

Abstract

Polysubstituted cyclopropane derivatives (3a-3h) could be obtained by reaction of activate olefinic compounds (2) with the cyanophosphates (1) aldehydes (benzaldehyde, cinnamaldehyde and croton-aldehyde) in the presence of butyllithium and tetra-methylethylenediamine in tetrahydrofuran via a Michael addition followed by 1,3-elimination.

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A New Synthesis of Polysubstituted Cyclopropanes

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A New Synthesis of Polysubstituted Cyclopropanes

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