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Abstract
The marine antibiotic mimosamycin, and a number of analogues, have been prepared in two steps by cycloaddition of a 1,4-benzoquinone or naphthoquinone with 2-aza-bis(1,3-t-butyldimethylsilyloxy)-1,3-buta-diene, hydrolytic work-up of the adduct, and phase-transfer catalysed alkylation of the resultant isoquinolin-3-ones.