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Abstract
Aminoxypropylamine (APA) has been found to be a potent inhibitor of several enzymatic pathways involved in the biosynthesis of the naturally occurring polyamines putrescine, spermidine, and spermine. This report describes a convenient, three-step synthesis of APA, as well as its ethyl and butyl homologs, utilizing starting materials and intermediates useful in the preparation of other related aminoxyalkylamines.