Dehydration of β-Hydroxy-α-amino Acid Derivatives With Phenyltriflimide

Abstract

Conversion of N-protected β-hydroxy-α-amino esters to corresponding didehydroamino esters has been achieved using phenyltriflimide/triethylamine as a mild dehydrating agent. The selective formation of didehydroalanine derivatives from dipeptides containing, beside a serine residue, another β-hydroxy-α-amino acid, is also described.