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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 19, 1989 - Issue 11-12
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Original Articles

An Improved Synthesis of L-Homohistidine

Janina Altman Department of Biophysics, Weizmann Institute of Science, Rehovot, Israel
,
Meir Wilchek Department of Biophysics, Weizmann Institute of Science, Rehovot, Israel
,
Ralph Lipp Institute of Pharmacy, Free University of Berlin, Königin Luise Str. 2+4, D-1000, Berlin (West)
&
Walter Schunack Institute of Pharmacy, Free University of Berlin, Königin Luise Str. 2+4, D-1000, Berlin (West)
Pages 2069-2076 | Received 03 Feb 1989, Published online: 24 Oct 2006
 
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Abstract

Bloemhoff - Kerling's method of L-homohistidine synthesis was modified by employing formamidine acetate in liquid ammonia for imidazole ring formation. The improved procedure significantly shortened the synthetic pathway and resulted in enhanced yield.

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