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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 19, 1989 - Issue 11-12
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Original Articles

Alkoxide-Induced Reaction of 1-[(Trimethylsilyl)-Methyl]Azoles with Imines and Carbonyl Compounds

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Pages 2219-2227 | Received 19 Nov 1988, Published online: 24 Oct 2006
 

Abstract

t-BuOK-induced reaction of 1-[(trimethylsilyl)methyl]-1,2,4-triazole with imines to yield (triazol-1- yl)ethylamines and (triazol-5-yl)methylamines was explored. Also, alkoxide-induced desilylation of 1-[(trimethylsilyl)methyl]azoles in the presence of carbonyl compounds was demonstrated, and (-BuOK and potassium trimethylsilanolate were found to be effective in this reaction.

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