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Abstract
Bromination of 1-(1-methyl-1H-pyrro]-2-yl)-2-phenylethanone with 1 mole of copper-(II) bromide in chloroform-ethyl acetate 1:1 mixture results in the regiospecific formation of 2-bromo-1-(1-methyl-1H-pyrrol-2-yl)-2-phenylethanone. Similar reaction with 1 mole of N-bromosuccinimide leads to α- and β-monosubstitution at pyrrole ring without affect the methylene group.