Nickel-Catalyzed Cyanation of 2- and 3- Bromothiophene

J. van Soolingen Department of Preparative Organic Chemistry of the University, Debye Institute, Padualaan 8, 3584, CH, Utrecht, The Netherlands

H. D. Verkruijsse Department of Preparative Organic Chemistry of the University, Debye Institute, Padualaan 8, 3584, CH, Utrecht, The Netherlands

M. A. Keegstra Department of Preparative Organic Chemistry of the University, Debye Institute, Padualaan 8, 3584, CH, Utrecht, The Netherlands

L. Brandsma Department of Preparative Organic Chemistry of the University, Debye Institute, Padualaan 8, 3584, CH, Utrecht, The Netherlands

Abstract

Trans-chloro-(2-naphthyl)-bis-(triphenylphosphine)nickel has been used to catalyze the conversion of 2-and 3-bromothiophene with alkali cyanide into the corresponding nitriles. A modified procedure for preparing the catalyst is described.

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Nickel-Catalyzed Cyanation of 2- and 3- Bromothiophene

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Nickel-Catalyzed Cyanation of 2- and 3- Bromothiophene

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