Enzymic Optical Resolution of α,α-Difluoro-β-Hydroxyketones

Takashi Tsukamoto Department of Bioengineering, Tokyo Institute of Technology, Ookayama, Meguro-ku, Tokyo, 152, Japan

Takashi Yamazaki Department of Bioengineering, Tokyo Institute of Technology, Ookayama, Meguro-ku, Tokyo, 152, Japan

Tomoya Kitazume Department of Bioengineering, Tokyo Institute of Technology, Ookayama, Meguro-ku, Tokyo, 152, Japan

Abstract

Kinetic resolution of various α,α-difluoro-β-hydroxyketones was conducted by enantioselective hydrolysis of the corresponding acetates with lipase MY to afford optically active products. Both enantiomers of 3,3-difluoro-2-hydroxy-4-decanone were obtained in a highly enantioselective manner by screening enzymes and acyl groups.

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Enzymic Optical Resolution of α,α-Difluoro-β-Hydroxyketones

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Enzymic Optical Resolution of α,α-Difluoro-β-Hydroxyketones

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