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Abstract
Various N-protected aminoacylimidazolides undergo decarboxylative carbon acylation with sodium or potassium nonomethylmalonate in THE in the presence of MgCl2, CoCl2 or MnCl2 to give dipeptide analogues (3) in 45–82% isolated yield. Amino Ketoester (3e) undergoes intramolecular cyclization induced by diisopropylethylamine and anhydrous magnesium chloride to trisubstituted tetramic acid (4).