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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 20, 1990 - Issue 10
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Original Articles

Synthesis of Polysubstituted Aromatic Acids Using an Intramolecular Benzyne Cyclisation

David R. Reavill Department of Medicinal Chemistry, Smith Kline and French Research, The Frythe, Welwyn, Herts, AL6 9AR
&
Stewart K. Richardson Department of Medicinal Chemistry, Smith Kline and French Research, The Frythe, Welwyn, Herts, AL6 9AR
Pages 1423-1436 | Received 12 Feb 1990, Published online: 24 Oct 2006
 
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Abstract

The protected haloanilines 3 and 4 undergo base catalysed elimination of halide to give aryne intermediates. These serve as useful precursors for the synthesis of the aromatic acids 7 and 8.

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