The Transformation of Nitriles into Amides Using Sodium Percarbonate

Abstract

The usefulness of sodium percarbonate, an inexpensive, safe and easily handled reagent for the transformation of nitriles into amides was investigated. Aromatic nitriles lacking ortho-substituents and heteroaromatic nitriles were efficiently transformed into amides; while ortho-substituted aromatic nitriles and aliphatic nitriles gave moderate yields of the corresponding amides.