Asymmetric Synthesis X: The High Enantioselective Synthesis of (R)-α-Substituted Benzylic Amines Via the Modified (+)-Camphor Derivative as Chiral Synthon

Abstract

A new chiral synthon-10-substituted (+)-camphor derivative (III) is synthesized. The alkylation of the (III) with a variety of alkylating agents gives the high enantioselectivity ranging from 72–100%e. e. And the crystal structures of the (III) and (IV) are involved in explaining the results.