Synthesis of Methyl-O-4,6-methylene-D-mannopyranoside by Transacetalisation Reaction from Dimethoxymethane

Abstract

Lithium bromide assisted transacetalisation of methyl-α-D-mannopyranoside (3) with dimethoxymethane led to the title compound (4) in moderate yield. Compound 4 is a new and stable monoacetal which is formed to the exclusion of the expected corresponding diacetal (5) or the rearranged diacetal (6).