A Novel Route to N-Alkylated Derivatives of Aziridine-2-Carboxylic Acid. an Alternative Synthesis of (S,S)-Bz-Azy-Val-OMe

Abstract

A novel method for N-alkylation of azyridine-2-oarboxylic acid derivatives with benzyl chloride under phase-transfer conditions or using KF/Al₂ O₃ as a base was developed. The latter variant of this method was applied to carry out the key step of the alternative synthesis of the dipeptide (S,S)-Bz-Azy-Val-OMe.