The Synthesis of 7-Alkoxyindoles

David Dobson Chemistry Department, Eli Lilly and Co. Ltd., Lilly Research Centre Ltd., Erl Wood Manor, Windlesham, Surrey, GU20 6PH, England

Alec Todd Chemistry Department, Eli Lilly and Co. Ltd., Lilly Research Centre Ltd., Erl Wood Manor, Windlesham, Surrey, GU20 6PH, England

Jeremy Gilmore Chemistry Department, Eli Lilly and Co. Ltd., Lilly Research Centre Ltd., Erl Wood Manor, Windlesham, Surrey, GU20 6PH, England

Abstract

A number of protected 7-hydroxyindoles was prepared by reaction of the protected 2-nitrophenols with vinylmagnesium bromide. Benzhydryl was shown to be the protecting group of choice, giving good yields of the indole and being readily removed for subsequent transformations of the 7-hydroxy function.

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The Synthesis of 7-Alkoxyindoles

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The Synthesis of 7-Alkoxyindoles

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