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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 21, 1991 - Issue 5
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Original Articles

A Convenient Preparation of 8-Ethyl-4,9-dihydro-3H-pyrano[3,4-b]indole-1-one, Key Intermediate of the Antiinflammatory Agent Etodolac

Asensio González Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, 08028, Barcelona, Spain
Pages 669-674 | Received 07 Jan 1991, Published online: 23 Sep 2006
 
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Abstract

A facile synthesis of 8-ethyl-4,9-dihydro-3H-pyrano [3,4-b]indole-1-one 5 is described which features the condensation of hydrazines with 2-oxo-5-hydroxypentanoic acid, followed by Fischer Cyclization of these adducts.

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