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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 21, 1991 - Issue 12-13
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Original Articles

Synthesis of Optically Active Cyanohydrins Using Almond Meal

P. Zandbergen Department of Chemistry, Gorlaeus Laboratories, Leiden University, P.O. Box 9502, 2300, RA, Leiden, The Netherlands
,
J. van der Linden Department of Chemistry, Gorlaeus Laboratories, Leiden University, P.O. Box 9502, 2300, RA, Leiden, The Netherlands
,
J. Brussee Department of Chemistry, Gorlaeus Laboratories, Leiden University, P.O. Box 9502, 2300, RA, Leiden, The Netherlands
&
A. van der Gen Department of Chemistry, Gorlaeus Laboratories, Leiden University, P.O. Box 9502, 2300, RA, Leiden, The Netherlands
Pages 1387-1391 | Received 08 Apr 1991, Published online: 23 Sep 2006
 
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Abstract

Asymmetric hydrocyanation of aldehydes was accomplished using almond meal, containing the enzyme oxynitrilase. Optically active cyanohydrins with high levels of enantiomeric purity were obtained following a simple procedure.

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