![Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/110819/TOC-Subject-Sample-2021-Physical-Sciences.jpg"})
Abstract
The novel reagent tetramethylammonium glycinate has been introduced as the most effective glycine derivative for the convenient synthesis of 4, 5, 6, 7-tetrahydroisoindoles (orpyrroles unsubstituted in the 2 and 5 positions) from 1,3-dicarbonyl compounds by [3+2] cyclization. The reaction has been shown to be catalyzed by 2,6-di(tert.buty1) pyridine reagents to triple the reported yield.