A New Synthesis of 8-Hydroxy-2-di-n-propylamino-tetralin (8-OH-DPAT): Synthetic Communications: Vol 22, No 12

Synthetic Communications

An International Journal for Rapid Communication of Synthetic Organic Chemistry

Volume 22, 1992 - Issue 12

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Abstract

A new synthesis method for 8-OH-DPAT, a specific agonist at the 5-HT_1A serotonin receptor, is described. It employs the Curtius degradation of a tetralin carboxylic acid easily prepared from (2-methoxy benzyl) succinic acid by Friedel-Crafts cyclisation.

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A New Synthesis of 8-Hydroxy-2-di-n-propylamino-tetralin (8-OH-DPAT)

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A New Synthesis of 8-Hydroxy-2-di-n-propylamino-tetralin (8-OH-DPAT)

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