Fischer Indole Synthesis of (β-Oxo)indol-3-yl Ketones Using Protected 1,3-Dicarbonyl Compounds

Luis G. Zepeda Departamento de Química del Centro de Investigación y de Estudios Avanzados, Instituto Politécnico Nacional, Apartado Postal 14-740, Mexico City, 07000, México

Martha S. Morales-Rios Departamento de Química del Centro de Investigación y de Estudios Avanzados, Instituto Politécnico Nacional, Apartado Postal 14-740, Mexico City, 07000, México

Pedro Joseph-Nathan Departamento de Química del Centro de Investigación y de Estudios Avanzados, Instituto Politécnico Nacional, Apartado Postal 14-740, Mexico City, 07000, México

Abstract

The condensation products of 4-methoxyphenylhydrazine and 3,3-dimethylenedithio-5-oxyaldehydes undergo Fischer cyclization to the corresponding indoles. The carbonyl-protecting group can be removed from the latter with formation of (β-oxo)indol-3-yl ketones.

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Fischer Indole Synthesis of (β-Oxo)indol-3-yl Ketones Using Protected 1,3-Dicarbonyl Compounds

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Fischer Indole Synthesis of (β-Oxo)indol-3-yl Ketones Using Protected 1,3-Dicarbonyl Compounds

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