Utilization of Chloroagetone in the Synthesis of 3-Methylindoles

Russell Underwood Sandoz Research Institute East Hanover, New Jersey, 07936, USA

Kapa Prasad Sandoz Research Institute East Hanover, New Jersey, 07936, USA

Oljan Repic Sandoz Research Institute East Hanover, New Jersey, 07936, USA

Goetz E. Hardtmann Sandoz Research Institute East Hanover, New Jersey, 07936, USA

Abstract

Syntheses of 3-methylindoles 2 and 5 are described starting from chloroacetone and the corresponding monoalkylated anilines utilizing a modified alkylation-cyclization sequence. Compound 5 was converted in high yield into a very useful oxindole 7 in two steps.

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Utilization of Chloroagetone in the Synthesis of 3-Methylindoles

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Utilization of Chloroagetone in the Synthesis of 3-Methylindoles

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