Chemo-Enzymatic Synthesis of Fmoc-Peptide Fragments

Shui-Tein Chen Institute of Biological Chemistry, Academia Sinica, P. O. Box 23—106, Taipei, Taiwan, 10098

Shu-Chyong Hsiao Institute of Biological Chemistry, Academia Sinica, P. O. Box 23—106, Taipei, Taiwan, 10098

Chung-Ho Chang Institute of Biological Chemistry, Academia Sinica, P. O. Box 23—106, Taipei, Taiwan, 10098

Kung-Tsung Wang Institute of Biological Chemistry, Academia Sinica, P. O. Box 23—106, Taipei, Taiwan, 10098

Abstract

Optically pure Fmoc-peptide fragments have been prepared via dicyclohexylcarbodiimide coupling of N-protected amino acids with amino acid esters, followed by enzyme-catalyzed ester hydrolysis by alcalase with a high concentration of organic solvent in a high yield.

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Chemo-Enzymatic Synthesis of Fmoc-Peptide Fragments

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Chemo-Enzymatic Synthesis of Fmoc-Peptide Fragments

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