N-Acyltetrazole as an Intermediate for Preparation of Carboxylic Acid Derivatives

Abstract

A new mild and very efficient procedure for preparation of acid derivatives via N-acyl-5-phenyltetrazole is reported. The yields are high at −10°C and purification is simple but, because of the thermal instability of the intermediate, a certain amount of corresponding oxadiazole arises if the reaction is carried out at higher temperature.