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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 23, 1993 - Issue 9
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Original Articles

Mitsunobu Reactions for the Synthesis of Carbocyclic Analogues of Nucleosides: Examination of the Regioselectivity1

Akemi Toyota Pharmaceutical Institute, Tohoku University, Aobayama, Sendai, 980, Japan
,
Nobuya Katagiri Pharmaceutical Institute, Tohoku University, Aobayama, Sendai, 980, Japan
&
Chikara Kaneko Pharmaceutical Institute, Tohoku University, Aobayama, Sendai, 980, Japan
Pages 1295-1305 | Received 01 Oct 1992, Published online: 24 Sep 2006
 
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Abstract

In order to provide a general synthetic method for carbocyclic nucleosides, regioselectivities in Mitsunobu reaction of purine, pyrimidin-2-one and their substituted derivatives with a variety of alcohols were examined and found to depend upon both substituents of the bases and kind of the alcohols.

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