Oxazolo[4,5-b]pyridines. Regiochemistry of Electrophilic Substitution in the 2-Diethylaminooxazolo[4,5-b]pyridine System: Synthesis of 6-Substituted Derivatives

Abstract

Electrophilic substitution occurs regiospecifically at C-6 in the 2-diethylaminooxazolo-[4,5-b]pyridine system to provide 6-nitro and 6-halo derivatives. The 6-nitro compound is readily converted to the 6-amino derivative which may be further elaborated by standard methods to provide more complex derivatives.