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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 23, 1993 - Issue 11
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Original Articles

A Large Scale Preparation of the Cognitive Enhancer Linopirdine

Walter M. Bryant III The Du Pont Merck Pharmaceutical Company, Process Research Facility, Chambers Works, Deepwater, New Jersey, 08023
,
George F. Huhn The Du Pont Merck Pharmaceutical Company, Process Research Facility, Chambers Works, Deepwater, New Jersey, 08023
,
James H. Jensen The Du Pont Merck Pharmaceutical Company, Process Research Facility, Chambers Works, Deepwater, New Jersey, 08023
,
Michael E. Pierce The Du Pont Merck Pharmaceutical Company, Process Research Facility, Chambers Works, Deepwater, New Jersey, 08023
&
C. Stammbach Siegfried Chemie Ag, Zofingen, Switzerland
Pages 1617-1625 | Received 13 Jan 1993, Published online: 23 Sep 2006
 
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Abstract

Linopirdine is a pharmacologically potent drug which stimulates central nervous system neurotransmitter release. A facile process used to synthesize linopirdine on a commercial manufacturing scale consisting of seven chemical steps with only a single isolated intermediate is described.

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