The Synthesis of Substituted 2-Aminophenyl Heterocyclic Ketones

R. I. Fryer Department of Chemistry Rutgers, The State University of New Jersey, 73 Warren Street, Newark, NJ, 07102

P. Zhang Department of Chemistry Rutgers, The State University of New Jersey, 73 Warren Street, Newark, NJ, 07102

R. Rios Department of Chemistry Rutgers, The State University of New Jersey, 73 Warren Street, Newark, NJ, 07102

Abstract

The synthesis of substituted 2-aminophenyl heterocyclic ketones, key intermediates to the preparation of 1,4-benzodiazepines has been achieved in one step and in good, yield from the corresponding anthranilic acid, by treatment with heterocyclic lithium reagents and chlorotrimethylsilane.

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The Synthesis of Substituted 2-Aminophenyl Heterocyclic Ketones

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The Synthesis of Substituted 2-Aminophenyl Heterocyclic Ketones

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