A Mild, Nonacidic Method for the Conversion of Carboxylic Esters into Oxazolines

J. H. Dodd The R. W. Johnson Pharmaceutical Research Institute, 1000 Route 202 Raritan, New Jersey, 08869

J. Guan The R. W. Johnson Pharmaceutical Research Institute, 1000 Route 202 Raritan, New Jersey, 08869

C. F. Schwender The R. W. Johnson Pharmaceutical Research Institute, 1000 Route 202 Raritan, New Jersey, 08869

Abstract

Conversion of carboxylic esters directly into amide alcohols is facilitated by use of base. Combined with a nonacidic cyclization of the intermediate amide alcohol this method allows formation of oxazolines under nonacidic conditions directly from the carboxylic esters.

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A Mild, Nonacidic Method for the Conversion of Carboxylic Esters into Oxazolines

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A Mild, Nonacidic Method for the Conversion of Carboxylic Esters into Oxazolines

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