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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 23, 1993 - Issue 8
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Original Articles

A New Synthesis of the Potent 5-HT1 Receptor Ligand, 5-Carboxyamidotryptamine (5-CT)

Atul Agarwal Department of Medicinal Chemistry, College of Pharmacy, University of Georgia, Athens, GA, 30602-2352
,
R. K. Jalluri Department of Medicinal Chemistry, College of Pharmacy, University of Georgia, Athens, GA, 30602-2352
,
C. DeWitt Blanton Jr. Department of Medicinal Chemistry, College of Pharmacy, University of Georgia, Athens, GA, 30602-2352
&
E. Will Taylor Department of Medicinal Chemistry, College of Pharmacy, University of Georgia, Athens, GA, 30602-2352
Pages 1101-1110 | Received 30 Oct 1992, Published online: 23 Sep 2006
 
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Abstract

A short, convenient and relatively efficient synthesis of 5-CT is developed through a modified Michael reaction. This method represents a new general synthesis for tryptamines with labile indole substituents.

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