A Direct Synthesis of Substituted α - Allenic Carboxanilides from Allenyllithium Reagents

P. Audin Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 8 avenue Rockefeller, 69373, Lyon Cedex 08, France

G. Drut-Grevoz Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 8 avenue Rockefeller, 69373, Lyon Cedex 08, France

J. Paris Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 8 avenue Rockefeller, 69373, Lyon Cedex 08, France

Abstract

The metalation of various allenic hydrocarbons and the subsequent reaction of the lithioderivatives with phenyl isocyanates as a synthetic route to α - allenyl carboxanilides is described. The best results were obtained with 3,3-disubstituted propadiene and 3,3,1-trisubstituted propadiene.

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A Direct Synthesis of Substituted α - Allenic Carboxanilides from Allenyllithium Reagents

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A Direct Synthesis of Substituted α - Allenic Carboxanilides from Allenyllithium Reagents

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