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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 23, 1993 - Issue 15
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Original Articles

A Convenient Preparation of (±)-α-Methoxy-α-trifluoromethylphenylacetic Acid (Mosher's Acid)

J. Michael Chong Department of Chemistry, University of Waterloo, Waterloo, Ontario, Canada, N2L 3G1
&
Rob Loewith Department of Chemistry, University of Waterloo, Waterloo, Ontario, Canada, N2L 3G1
Pages 2145-2150 | Received 04 Mar 1993, Published online: 23 Sep 2006
 
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Abstract

Mosher's Acid can be prepared from PhC(O)CF3 via a vinylation, methylation, ozonolysis/oxidation sequence in >80% overall yield.

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