A New Facile One-Pot Synthesis of Cyclopropyl Vinyl Sulfides

Danielle Roche Groupe de Recherche en Pharmacochimie, U.F.R. de Pharmacie, B.P.38, F-63001, Clermont-Ferrand Cedex 1, France

Saiïda Danoun Groupe de Recherche en Pharmacochimie, U.F.R. de Pharmacie, B.P.38, F-63001, Clermont-Ferrand Cedex 1, France

Michel Madesclaire Groupe de Recherche en Pharmacochimie, U.F.R. de Pharmacie, B.P.38, F-63001, Clermont-Ferrand Cedex 1, France

Abstract

The (Z) and (E) diastereoisomers of cyclopropylvinyl sulfides are efficiently prepared by treatment of (phenylthiomethyl)trimethylsilane with γ-chlorobutyrophenones in the presence of LDA at −78°C. C3 ring closure and olefination by Peterson reaction occur in the same step.

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A New Facile One-Pot Synthesis of Cyclopropyl Vinyl Sulfides

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A New Facile One-Pot Synthesis of Cyclopropyl Vinyl Sulfides

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