A Facile Method for Detritylation of 5′-O-Dimethoxytrityl-3′-O-tert-butyldimethylsilyl-2′-deoxynucleosides

Sucheta V. Patil Dept. of Chemistry, Shivaji University, Kolhapur, 416 004, INDIA

Ramchandra B. Mane Dept. of Chemistry, Shivaji University, Kolhapur, 416 004, INDIA

Manikrao M. Salunkhe Dept. of Chemistry, Shivaji University, Kolhapur, 416 004, INDIA

Abstract

The dimethoxytrityl group can be removed effectively from 5′-O-dimethoxytrityl-3′-O-tert-butyl dimethylsilyl-2′-deoxynucleosides and their N-acyl derivatives by using sulfonated crosslinked (1% DVB) polystyrene in dichloromethane-methanol (97.5 : 2.5,v/v) without causing depurination. It has been observed that solvent and percentage of crosslinking plays important role in these reactions.

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A Facile Method for Detritylation of 5′-O-Dimethoxytrityl-3′-O-tert-butyldimethylsilyl-2′-deoxynucleosides

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A Facile Method for Detritylation of 5′-O-Dimethoxytrityl-3′-O-tert-butyldimethylsilyl-2′-deoxynucleosides

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