Synthesis of Methyl 3-Aryl 2-Isopropyl-aminomethylpropanoates Through Reduction of Methyl 3-Aryl 2-Isopropyl Aminomethylacrylates

Abstract

Hydrogenation of Boc-protected 3-aryl 2-aminomethylacrylic acid esters over 10% palladium on carbon in ethanol gives the Boc-protected β-amino esters 4. Deprotection of 4 with anhydrous hydrochloric acid gives the β-aminoester hydrochlorides 5. The treatment of 5 with sodium carbonate yields saturated β-amino esters 6.