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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 24, 1994 - Issue 8
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Original Articles

A Novel Synthesis of the 5HT3-Receptor Antagonist BRL 49231

Sandra J. Paknoham Synthetic Chemistry, SmithKline Beecham Pharmaceuticals, Coldharbour Road, The Pinnacles, Harlow, Essex, CM19 5AD, UK
&
Martyn Voyle Synthetic Chemistry, SmithKline Beecham Pharmaceuticals, Coldharbour Road, The Pinnacles, Harlow, Essex, CM19 5AD, UK
Pages 1091-1100 | Received 20 Sep 1993, Published online: 23 Sep 2006
 
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Abstract

A short route to the 5HT3 receptor antagonist BRL 49231 involving alkylation of the amide enolate of 1-acetyl-3,3-dimethylindoline is described.

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