Reduction and N-Alkylation of α-Methylene-indolines with Sodium Cyanoborohydride in Carboxylic Acids

Emilia R. Balogh Eötvös University Budapest, Institute of Chemistry, H-1518, Budapest, 112, P. O. Box 32, Hungary

Bela Zsadon Eötvös University Budapest, Institute of Chemistry, H-1518, Budapest, 112, P. O. Box 32, Hungary

Antal Csámpai Eötvös University Budapest, Institute of Chemistry, H-1518, Budapest, 112, P. O. Box 32, Hungary

R. Pál Hungarian Oil and Gas Co., Development and Marketing Division, H-2443, Százhalombatta, P. O. B. 1, Hungary

Abstract

The reaction of α-methylene-indolines with NaCNBH₃ in carboxylic acids at room temperature can yield either 2β,3β-dihydro-indolines or their N-alkyl derivatives as main products with high selectivity, depending mainly on the carboxylic acid and on the reaction time when using a large excess of NaCNBH₃.

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Reduction and N-Alkylation of α-Methylene-indolines with Sodium Cyanoborohydride in Carboxylic Acids

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Reduction and N-Alkylation of α-Methylene-indolines with Sodium Cyanoborohydride in Carboxylic Acids

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